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Diethylene Glycol Oligomer Squalene Derivative Improves Hepatic Metabolism and Attenuates Obesity-Related Dysmetabolism via Sirt-AMPK axis Activation

ABSTRACT: Transcriptomic analysis comprehensively revealed the metabolic improvement effects of di-SQ on the liver and white adipose tissue in ob/ob mice. Di-SQ demonstrated effects in improving inflammation and lipid metabolism in both the liver and white adipose tissue of ob/ob mice and restored the expression of genes and GO terms associated with mitochondrial respiration and glucose metabolism. The metabolic disorder observed in untreated ob/ob mice was reversed by a 42-day-di-SQ treatment, the di-SQ treated ob/ob mice showed a gene expression pattern in key metabolic pathways and processes that more closely resembles that of wild-type mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE281432 | GEO | 2024/12/10

REPOSITORIES: GEO

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