Single-Cell RNA Sequencing Reveals Age-Related Changes in Epidermal Cell Populations and Interactions
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ABSTRACT: Utilizing single-cell RNA sequencing, we analyzed epidermal cells from young (20-30 years old) and elderly (60+ years old) subjects. Our findings reveal that aged epidermis exhibits increased expression of inflammation-related genes and pathways associated with nonsense-mediated decay, oxidative phosphorylation, and apoptotic signaling, predominantly in keratinocytes. Furthermore, we observed a reduction in cell-to-cell interactions from the proliferative basal and granular layers to other epidermal cells. This study underscores how epidermal aging primarily impacts keratinocytes and diminishes intercellular interactions, unveiling a novel mechanism of skin aging.
ORGANISM(S): Homo sapiens
PROVIDER: GSE281449 | GEO | 2024/11/15
REPOSITORIES: GEO
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