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Transcriptomic changes in ER-HOXB8 mouse cell line on Phf6 knockout

ABSTRACT: PHF6 is a transcriptional regulator mutated in 3-5% of acute myeloid leukemia. To understand the effect of loss and clinical mutation of PHF6 on the transcriptome of myeloid cells we generated multiple wildtype and Phf6 knockout clones. We observed that loss of PHF6 upregulated genes related to stemness and downregulates genes related to myeloid differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE281625 | GEO | 2024/11/15

REPOSITORIES: GEO

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Transcriptomic changes in PHF6 knockout THP1 human AML cell line on rescue with PHF6 wildtype (with and without PHIP) or rescue with PHF6R274Q mutant

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