ScRNA sequencing of the small intestine lamina propria of laboratory and rewilded mice
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ABSTRACT: In rewilded mice, we observed B cells in circulation with increased signs of maturation, alongside heightened germinal center responses within secondary lymphoid organs. Rewilding also expanded B cells in the gut, which was accompanied by elevated systemic levels of IgG and IgM antibodies reactive to the microbiota. Our findings indicate that exposing laboratory mice to a more natural environment enhances B cell development to better reflect the immune system of free-living mammals.
ORGANISM(S): Mus musculus
PROVIDER: GSE282735 | GEO | 2024/11/29
REPOSITORIES: GEO
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