Transcriptomics

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Oxygen regulation of immunogenicity in primary human glioma cells


ABSTRACT: Dendritic Cell (DC) vaccination is a powerful approach for cancer immunotherapy that has recently obtained regulatory approval, and tumor lysate-pulsed DC vaccines are being tested in clinical trials. Tumor cell lysates (TLs) are often generated from cells cultured in atmospheric oxygen (~20% O2), which is roughly four-fold higher than that of the tumor in situ. We analyzed the expression patterns of glioma cells cultured in 5% Oxygen, 20% Oxygen and the primary tumors which the cell cultures were derived.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28316 | GEO | 2013/01/01

SECONDARY ACCESSION(S): PRJNA139333

REPOSITORIES: GEO

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