Transcriptomic comparison of long- vs. short-lived C. elegans
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ABSTRACT: Variability in lifespan among individuals of the same species is a poorly understood phenomenon. Even among isogenic C. elegans reared in identical environments, we observe considerable variance in lifepsan. To better understand the differences in gene expression that underly this variability, we characterized the transcriptomes associated with long vs. short lifespan. We isolated the longest- and shortest-lived members from their respective populations using biomarkers of aging--predictive markers whose expression levels correlate with an individual's future lifespan. Specifically, we sorted animals by the expression of lin-4p::GFP, mir-243p::GFP, mir-240/786p::GFP, and autofluorescence. All populations were chronologically five days old at time of sorting. We subsequently compared the transcriptomes of future lifespan within and between different biomarkers to identify a gene expression signature of future lifespan.
ORGANISM(S): Caenorhabditis elegans
PROVIDER: GSE283419 | GEO | 2024/12/09
REPOSITORIES: GEO
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