Transcriptomics

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Expression data from LSK mice that overpexpress Ezh2 versus LSK Control


ABSTRACT: Ezh2 is a protein member of PRC2 and has described like a functional repressor gene. We are investigating the role of Ezh2 in hematopoietic stem cell, aging and leukemia. In the present study, we generated mouse models that allow gain-of-function of Ezh2 in the hematopoietic system. Activation of Ezh2 expression specifically in self-renewing HSCs alters gene expression programs and severely compromises hematopoietic function, leading to the development of myeloproliferative disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE28369 | GEO | 2011/04/05

SECONDARY ACCESSION(S): PRJNA139433

REPOSITORIES: GEO

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