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BTLA agonist attenuates Th17 inflammation in a mouse model of steroid-resistant asthma

ABSTRACT: Mouse models of steroid-resistant asthma are needed to understand the pathophysiology of the disease in order for effective therapeutics to be developed. The BXD75 mice strain exhibited neutrophilic airway inflammation and steroid resistance. This study investigated the HVEM-BTLA signaling pathway in CD4+ T cells from BXD75 and C57BL/6J (WT) mice exposed to house dust mite (HDM).

ORGANISM(S): Mus musculus

PROVIDER: GSE284206 | GEO | 2025/03/13

REPOSITORIES: GEO

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