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Single cell RNA-Seq result of spinal cord of AR-97Q mice and AR-24Q mice at 6 weeks

ABSTRACT: To understand the early pathogenesis of SBMA and to systematically assess the role of different cells in the spinal cord of SBMA, we conducted snRNA-seq on the spinal cord of AR-97Q and AR-24Q mice at 6 weeks. The genes related to ion channel and synapse function were up-regulated in oligodendrocytes of AR-97Q mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE284338 | GEO | 2024/12/29

REPOSITORIES: GEO

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Single cell RNA-Seq result of spinal cord of AR-97Q mice and wild-type mice at four disease stages

Project description:To understand the early pathogenesis of SBMA and to systematically assess the role of different cells in the spinal cord of SBMA, we conducted snRNA-seq on the spinal cord of AR-97Q mice at different stages of the disease. The genes related to ion channel and synapse function were up-regulated in oligodendrocytes in early stages of SBMA although they were down-regulated at the advanced stage.

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