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The gene expression analysis of the spinal cord of SBMA (Spinal Bulbar Muscular Atrophy) model mice

ABSTRACT: To identify the gene expression changes that are specific to SBMA, we prepared total mRNA samples from the spinal cords of transgenic mice carrying a full-length human AR with 97 CAGs (AR-97Q), transgenic mice bearing a wild-type allele of AR with 24 CAGs (AR-24Q), and the wild-type littermates of the AR-97Q mice (C57BL/6). We used AR-97Q (Line #7-8) male mice because they show progressive muscular atrophy and weakness as well as SBMA-like pathology such as the accumulation of the pathogenic androgen receptor in the nucleus of motor neurons. Using microarray analysis, we identified the genes with significantly altered expression among the three types of mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE39865 | GEO | 2012/08/04

SECONDARY ACCESSION(S): PRJNA171891

REPOSITORIES: GEO

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The gene expression analysis of the spinal cord of SBMA (Spinal Bulbar Muscular Atrophy) model mice

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