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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance [bulk RNA-Seq]

ABSTRACT: Macrophages were identified in the pituitary gland long ago, but until recently, we lacked the resolution to comprehensively profile the pituitary gland macrophage compartment. To address this, we examined the developmental kinetics and distinctive characteristics of pituitary macrophages within the developing and homeostatic gland. Whole pituitary glands were collected from newborn (NB) to adult (8 weeks old) wild-type (WT) mice. Our analysis revealed diverse macrophage subsets with marked differences in gene expression profiles and spatial localization, undergoing dynamic phenotypic changes from neonatal stages to adulthood. We observed distinct transcriptional profiles between macrophage subpopulations in the anterior and posterior lobes, underscoring significant molecular divergences. Fate-mapping analyses showed that pituitary macrophages originate from early yolk sac precursors and persist throughout life primarily through local proliferation, even under pathophysiological conditions.

ORGANISM(S): Mus musculus

PROVIDER: GSE284384 | GEO | 2025/01/03

REPOSITORIES: GEO

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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance [scRNA-Seq]

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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

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