Hey3Met2 human ovarian cancer cells overexpressing wild type or catalytically-dead mutant RNASET2
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ABSTRACT: Hey3Met2 cells were stably transfected with plasmids encoding either wild-type RNASET2 or a catalytically dead form (whose cDNA has been previously mutagenized in the two CAS catalytic sites) or with the empty vector as a control. The control of ovarian tumorigenesis by RNASET2 occurs through modification of the cellular microenvironment and involvement of immunocompetent cells, thus providing evidence for specific modulations of cellular responses induced by RNASET2 that might underlay ovarian tumorigenesis. In order to get more inside on the effect of RNASET2 on the modulation of other genes, a whole genome expression has been run on Hey3Met2 cell transfected with wildtype or mutated RNASET2.
ORGANISM(S): Homo sapiens
PROVIDER: GSE28478 | GEO | 2011/06/01
SECONDARY ACCESSION(S): PRJNA139305
REPOSITORIES: GEO
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