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Molecular characterization of immortalization of human MSCs by a combination of p53 knockdown and TERT overexpression

ABSTRACT: Gene expression profile of p53 knockdown MSCs or p53 knockdown+TERT MSCs was compared with that of control MSCs. Our data show p53 knockdown prolongs the lifespan of MSCs, and a combination of p53 knockdown and TERT overexpression is sufficient to immortalize MSCs. The results provide important information about the molecular basis underlying p53 knockdown in MSCs and immortalization-related genes of MSCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28546 | GEO | 2011/04/13

SECONDARY ACCESSION(S): PRJNA139059

REPOSITORIES: GEO

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Molecular characterization of immortalization of human MSCs by a combination of p53 knockdown and TERT overexpression

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