Transcriptomics

Dataset Information

0

Genome-wide RNA expression in muscle-enriched embryos across different mutations.


ABSTRACT: To investigate the structure of the bodywall muscle differentiation network, we sought to both identify what these transcription factors regulate in bodywall muscle. Through loss of function analysis, we identified genome-wide regulatory targets of hlh-1 and unc-120 using RNA-seq. 1445 targets of hlh-1 and 3674 targets of unc-120 were identified, with 760 of these genes being targets of both. Crosstalk was identified between the networks of hlh-1 and hlh-8, which is involved in non-bodywall muscle development. In the process, we quantified bodywall muscle RNA. Our data suggest that shared target genes and overlapping regulation buffer the hlh-1 and unc-120 mutant phenotypes.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE28562 | GEO | 2012/06/22

SECONDARY ACCESSION(S): PRJNA143023

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-06-21 | E-GEOD-28562 | biostudies-arrayexpress
2012-06-21 | E-GEOD-28561 | biostudies-arrayexpress
2012-06-22 | GSE28561 | GEO
2020-09-19 | GSE158232 | GEO
2012-06-21 | E-GEOD-28563 | biostudies-arrayexpress
2024-07-16 | PXD045081 | Pride
2011-02-18 | E-GEOD-25784 | biostudies-arrayexpress
2013-07-11 | E-GEOD-48752 | biostudies-arrayexpress
2013-07-11 | E-GEOD-48751 | biostudies-arrayexpress
| PRJNA139037 | ENA