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HLH-1 binding in muscle-enriched embryos and RNA expression in muscle-enriched embryos across different mutations

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE28563 | GEO | 2012/06/22

SECONDARY ACCESSION(S): PRJNA139037

REPOSITORIES: GEO

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HLH-1 binding in muscle-enriched embryos and RNA expression in muscle-enriched embryos across different mutations

Project description:This SuperSeries is composed of the following subset Series: GSE28561: Genome-wide maps of HLH-1 binding in muscle-enriched embryos. GSE28562: Genome-wide RNA expression in muscle-enriched embryos across different mutations. Refer to individual Series

2012-06-21 | E-GEOD-28563 | biostudies-arrayexpress

HLH-1 binding in muscle-enriched embryos and RNA expression in muscle-enriched embryos across different mutations

Project description:HLH-1 binding in muscle-enriched embryos and RNA expression in muscle-enriched embryos across different mutations

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Genome-wide maps of HLH-1 binding in muscle-enriched embryos.

Project description:To investigate the structure of the bodywall muscle differentiation network, we sought to both identify what role HLH-1 binding has in this regulation. We mapped the relationship between the regulatory targets and HLH-1 binding, as measured by ChIP-seq in animals enriched for bodywall muscle tissue through RNAi feeding. While regulatory targets are enriched for HLH-1 binding, the majority of HLH-1 binding actually occurs away from genes that are affected by hlh-1 loss of function. Nevertheless, HLH-1 binding is associated with both the expected E-box and, near genes belonging to specific regulatory subgroups, novel motifs that may serve as binding sites for cooperative transcription factors.

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Project description:To investigate the structure of the bodywall muscle differentiation network, we sought to both identify what these transcription factors regulate in bodywall muscle. Through loss of function analysis, we identified genome-wide regulatory targets of hlh-1 and unc-120 using RNA-seq. 1445 targets of hlh-1 and 3674 targets of unc-120 were identified, with 760 of these genes being targets of both. Crosstalk was identified between the networks of hlh-1 and hlh-8, which is involved in non-bodywall muscle development. In the process, we quantified bodywall muscle RNA. Our data suggest that shared target genes and overlapping regulation buffer the hlh-1 and unc-120 mutant phenotypes.

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