Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

ABSTRACT: To investigate the effect of DOPAC on CD8+ T cells function, CD8+ T cells were treated with DOPAC for bulk RNA sequcecing.

ORGANISM(S): Mus musculus

PROVIDER: GSE287296 | GEO | 2025/01/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of control and FK866-treated ILC2s in vitro

Project description:To investigate the effect of NAD+ metabolism on ILC2s function, sorted ILC2s from the gut were treated with NAMPT inhibitor FK866 for bulk RNA sequcecing.

2022-11-22 | GSE218368 | GEO

CD8 T cells isolated from treated mice

Project description:CD8 T cells isolated from blood of mice treated with radiation therapy and immunotherapy

2024-06-20 | PXD043110 | JPOST Repository

RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

Project description:RNA-seq of control and DOPAC-treated CD8+ T cells in vitro

| PRJNA1212056 | ENA

Bulk RNA sequence and bulk ATAC sequence of treated murine CD8+ T cells

Project description:Bulk RNA sequence and bulk ATAC sequence of treated murine CD8+ T cells

| PRJNA787632 | ENA

Effect of STAT3-/+ secretome in CD8+ T cells in vitro culture

Project description:To investigate the effect of the addition of STAT3-/+ astrocyte derived-conditioned medium in CD8+ T cells previously activated in vitro We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 CD8+ T cells cultures of STAT3- conditon and 3 CD8+ T cells cultures of STAT3+ conditon

2024-08-30 | GSE228364 | GEO

Exhausted-like CD8 T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects - sorted CD8 subsets

Project description:Bulk RNA-sequencing of sorted CD8 T cell subsets from recent-onset T1D subjects treated with alefacept

2020-12-23 | GSE163731 | GEO

Effect of bryostatin-1 on in vitro exhausted CD8+ T cells

Project description:Bryostatin-1, a pharmacological agent from marine organisms, has been studied for HIV and cancer therapies due to its modulation of protein kinase C. In our previous study (Zhao M et al. Pharmacological research. 2019;139:524-34.), we found that bryostatin-1 downregulated inhibitory receptor PD-1 on activated CD8+ T cells from people with HIV. Since HIV-specific CD8+ T cells become functionally exhausted during chronic HIV infection and PD-1 expression is known to be related to the exhaustion state of these cells, we hypothesized that bryostatin-1 may modulate CD8+ T cell exhaustion. To test this, we generated in vitro exhausted OT-I CD8+ T cells as previously described (Zhao M et al PLoS Pathog. 16(6): e1008555) by repeatedly stimulating cells with OVA(257-264) peptide. Then we treated both exhausted CD8+ T cells (repeat peptide stimulated cells) and non-exhausted CD8+ T cells (single peptide stimulated cells) with bryostatin-1 for 3 days. We found that bryostatin-1 decreased exhaustion-associated markers and improved the functionality of exhausted CD8+ T cells. To investigate the underlying mechanism of how bryostatin-1 exerts its effects on exhausted CD8+ T cells, we performed RNA-sequencing (RNA-seq) on in vitro exhausted OT- I CD8+ T cells which were treated with bryostatin-1 or DMSO, with single peptide stimulated cells as non-exhausted controls. Taken together, our study demonstrate bryostatin-1's effect on exhausted CD8+ T cells and bryostatin-1's potential in enhancing T cell immunity against chronic infection or cancer.

2025-01-06 | GSE284406 | GEO

Distinct exhausted CD8 T cell populations are linked to C-peptide preservation in alefacept-treated, recent onset T1D subjects

Project description:Bulk RNA-sequencing of sorted CD8 T cells from recent-onset T1D subjects treated with alefacept.

2020-12-10 | GSE158292 | GEO

Human CD8 T central memory (Tcm) cells: Control vs. norepinephrine (NE) treated

Project description:Transcriptional profiling of CD8 Tcm cells comparing untreated control cells to 16 hour norepinephrine treated cells. The goal was to examine the impact of norepinephrine treatment on CD8 Tcm cell global gene expression compared to untreated cells, and also to examine changes that occurred in resting cells and activated cells 24 and 72 hours after stimulation with CD3/28 beads. Two-conditional experiment: Control vs. NE treated CD8 Tcm cells. Biological replicates: 3 replicates for 0 hour and 24 hours, and 2 replicates for 72 hours. Each sample consisted of pooled RNA from 3 different donors.

2015-03-01 | E-GEOD-64635 | biostudies-arrayexpress

CUT&Tag seq of control, FK866-, FK866 plus succinate-treated ILC2s in vitro

Project description:To investigate the effect of NAD+ metabolism on ILC2s, sorted ILC2s from the gut were treated with FK866 or FK866 plus succinate for CUT-Tag sequcecing.

2024-03-12 | GSE261263 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data