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Inhalable liposomal delivery of osimertinib and DNA for treating primary and metastatic lung cancer

ABSTRACT: Lung cancer is one of the most prevalent cancers, and brain metastases significantly worsen the prognosis for patients. We developed an inhalable surfactant-based biomimetic nanoliposome system (MPDOLs) to co-deliver Osimertinib and DNA plasmids to deplete IGF2BP3 expression. To investigate how MPDOLs influence gene expression and therapeutic outcomes by targeting IGF2BP3 and co-delivering Osimertinib, we performed transcriptomic analysis of MPDOL treated Lewis lung cancer cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE289979 | GEO | 2025/03/10

REPOSITORIES: GEO

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