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ChIP-seq profiling of estrogen receptor binding in MCF-7 cells exposed to 5α-DTT, Flutamide, Estradiol, and Bisphenol B

ABSTRACT: Endocrine-disrupting chemicals (EDCs) can modulate estrogen receptor (ER) signaling by altering its transcriptional activity. To investigate these effects, we performed chromatin immunoprecipitation sequencing (ChIP-seq) on cells treated with 5α-Dihydrotestosterone (5α-DTT), Flutamide, Estradiol, and Bisphenol B. This dataset includes raw sequencing reads, processed peak files, and metadata, enabling the identification of ER binding sites influenced by each EDC. Gene ontology (GO) analysis of ChIP-enriched regions revealed that these compounds affect key pathways, including antibody-dependent cytotoxicity, BMP signaling in cardiac induction, and hepatocyte growth factor receptor signaling. This dataset provides insights into EDC-induced transcriptional regulation and contributes to the understanding of their role in endocrine disruption.

ORGANISM(S): Homo sapiens

PROVIDER: GSE291416 | GEO | 2025/03/12

REPOSITORIES: GEO

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ChIP-seq profiling of estrogen receptor binding in MCF-7 cells exposed to 5α-DTT, Flutamide, Estradiol, and Bisphenol B

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