Transcriptomics

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To study glycosaminoglycan (GAG) glycogene expression in cutaneous lupus erythematosus (CLE) skin lesions and normal skin


ABSTRACT: Cutaneous lupus erythematosus (CLE) is an autoimmune disease that localizes to the skin and is known to contain elevated glycosaminoglycans (GAGs) on Hale’s stain of skin biopsy specimens. Recently, different GAG species have been shown to have distinct effects on the recruitment and activation of immune cells and stimulation of cytokine production (Taylor and Gallo, FASEB, 2006; 20: 9-22). Thus, we speculate that the elevated GAGs observed in CLE play a role in the local inflammatory process that produces skin lesions in these patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE29938 | GEO | 2011/06/14

SECONDARY ACCESSION(S): PRJNA140889

REPOSITORIES: GEO

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