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The GntR family repressor YtrA responds to cell wall antibiotics

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Bacillus subtilis

PROVIDER: GSE30003 | GEO | 2011/06/17

SECONDARY ACCESSION(S): PRJNA143673

REPOSITORIES: GEO

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The GntR family repressor YtrA responds to cell wall antibiotics

Project description:This SuperSeries is composed of the following subset Series: GSE30001: Bacillus subtilis 168 moenomycin stimulon GSE30002: Bacillus subtilis CU1065 ramoplanin stimulon Refer to individual Series

2011-06-17 | E-GEOD-30003 | biostudies-arrayexpress

The Bacillus subtilis GntR family repressor YtrA responds to cell wall antibiotics.

Project description:The transglycosylation step of cell wall synthesis is a prime antibiotic target because it is essential and specific to bacteria. Two antibiotics, ramoplanin and moenomycin, target this step by binding to the substrate lipid II and the transglycosylase enzyme, respectively. Here, we compare the ramoplanin and moenomycin stimulons in the Gram-positive model organism Bacillus subtilis. Ramoplanin strongly induces the LiaRS two-component regulatory system, while moenomycin almost exclusively induces genes that are part of the regulon of the extracytoplasmic function (ECF) ? factor ?(M). Ramoplanin additionally induces the ytrABCDEF and ywoBCD operons, which are not part of a previously characterized antibiotic-responsive regulon. Cluster analysis reveals that these two operons are selectively induced by a subset of cell wall antibiotics that inhibit lipid II function or recycling. Repression of both operons requires YtrA, which recognizes an inverted repeat in front of its own operon and in front of ywoB. These results suggest that YtrA is an additional regulator of cell envelope stress responses.

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