Genomics

Dataset Information

0

IkBa associates with histone H2A in human keratinocytes


ABSTRACT: Here, we demonstrate that IkBa displays a predominant and unique nuclear localization in normal basal keratinocytes. This nuclear IkBa binds the chromatin through direct interaction of the ankyrin repeats with histone H2A and associates with the promoter and regulatory regions of several developmental-related genes including HOXA10, HOXB2 and HOXB9. Most importantly, IkBa dictates the competence of these HOX genes to be activated upon TNFa stimulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30082 | GEO | 2013/08/01

SECONDARY ACCESSION(S): PRJNA144069

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-08-01 | E-GEOD-30082 | biostudies-arrayexpress
2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
2012-12-31 | GSE8334 | GEO
| S-EPMC4882029 | biostudies-literature
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
2012-12-31 | GSE8009 | GEO
2018-06-05 | GSE115311 | GEO
2021-12-21 | GSE176286 | GEO
| PRJNA130365 | ENA
2023-01-31 | GSE223763 | GEO