Transcriptomics

Dataset Information

0

Vitamin D3 affects TNFa mediated activation of dendritic cells


ABSTRACT: The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of NF-kB target genes that are central to DC biology is largely unknown. In the present study inhibition of the NF-kB activation by the IkBa super repressor (IkBa-SR) and DNA microarray analysis were used to determine the repertoire of NF-kB responsive genes in DC. A number of immunomodulatory compounds have been suggested to target the NF-kB signalling pathway and/or NF-kB-mediated transcription of pro-inflammatory target genes. 1a,25-dihydroxyvitamin D3 (VD3) exerts its effects through the vitamin D3 receptor (VDR), a member of the nuclear hormone receptor superfamily. Microarray analysis was also selected as an approach of choice for the analysis of the effects of VD3 on the activation of DC, and to survey the involvement of VDR in repression of NF-kB regulated genes. These genes can be potentially useful targets for the development of more specific anti-inflammatory agents for clinical applications. Keywords: drug treatment, TNFa treatment, VD3 treatment

ORGANISM(S): Mus musculus

PROVIDER: GSE8334 | GEO | 2012/12/31

SECONDARY ACCESSION(S): PRJNA101331

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
2012-12-31 | GSE8009 | GEO
2012-12-31 | E-GEOD-8009 | biostudies-arrayexpress
2024-05-09 | PXD037534 | JPOST Repository
| PRJNA100801 | ENA
2023-05-10 | PXD040622 | Pride
2020-09-28 | PXD019876 | Pride
2009-07-22 | GSE17129 | GEO
2008-06-14 | E-GEOD-6324 | biostudies-arrayexpress
2009-08-11 | GSE12434 | GEO