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Retinoic acid (RA) induction time-course to profile gene expression during mES cell differentiation.

ABSTRACT: Murine ES cell gene expression before RA induction are used to compare gene expression for time-points of 2, 4, 6hrs post-induction.

ORGANISM(S): Mus musculus

PROVIDER: GSE30176 | GEO | 2011/07/19

SECONDARY ACCESSION(S): PRJNA155201

REPOSITORIES: GEO

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Retinoic acid (RA) induction time-course to profile gene expression during mES cell differentiation.

Project description:Murine ES cell gene expression before RA induction are used to compare gene expression for time-points of 2, 4, 6hrs post-induction. KH2 ES Cell RA Differentiation Time-course

2011-07-18 | E-GEOD-30176 | biostudies-arrayexpress

Retinoic acid (RA) induction time-course to profile gene expression during mES cell differentiation

Project description:Murine ES cell gene expression before RA induction are used to compare gene expression for time-points of 8, 12, 16, 24, 36, 48, 60 and 72 hours post-induction.

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Retinoic acid (RA) induction time-course to profile gene expression during mES cell differentiation

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THP-1 cell study: RA and TNF Treatments; RA time course

Project description:The study consisted of two experiments. The hypothesis tested was that RA and tumor necrosis factor (TNF)-alpha would independently and synergistically regulate the expression of genes in THP-1 human myeloid cells, and that RA alone would be a significant modulator, as tested in a kinetic experiment.

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LOXL2 dependent genes in RA induced mES differentiation

Project description:Our results indicate that oxidation of TAF10 by LOXL2 induces its release from its promoters, leading to a block in TFIID-dependent gene transcription. Since TFIID complex is crucial for the expression of Nanog, Klf4, Sox2 and Oct4 and for maintaining the pluripotent state of embryonic stem cells, TAF10 oxidation by LOXL2 leads to inactivation of the pluripotency genes and a loss of pluripotent capacity in embryonic stem cells. Moreover, in vivo results demonstrate an essential role of LOXL2 in neural differentiation during zebrafish development: in the absence of LOXL2 the neural progenitor gene Sox2 is aberrantly overexpressed and neural differentiation is impaired. 12 samples were analyzed: mES transduced with control shRNA (n=3); mES transduced with LOXL2 shRNA (n=3), ES transduced with control shRNA and treated with RA (n=3); ES transduced with LOXL2 shRNA and treated with RA (n=3)

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Neural induction (Embrioid bodies-Retinoic acid)

Project description:Neural induction of ES by Retinoic acid Neural induction of ES by Retinoic acid

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Project description:Neural induction of ES by Retinoic acid Keywords: development or differentiation design,time series design

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Retinoic Acid Is Sufficient for the in vitro Induction of Mouse Spermatocytes

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Retinoic Acid Is Sufficient for the in vitro Induction of Mouse Spermatocytes

Project description:To identify RA-regulated genes in mSSCs, we treated mSSCs with vehicle, RA and RA plus CHX. To characterize the induced spermatogenic cells by transcriptome profiling, we cultured mSSCs on pup Sertolic cells supplemented with RA. Induced differentiating spermatogonia and induced spermatocytes were collected after a 3-day- and 6-day-induction, respectively. We carried out RNA-seq analysis of samples after different treatment and samples from different in vitro induction stages.Two biological replicates were included for each sample.

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Gene regulation by phosphomimetic Myc (MycD), cytosine arabinoside (AraC) and retinoic acid (RA)

Project description:We aimed to investigate whether the previously observed synergistic effects of AraC and RA in stimulating leukemia differentiation could be at least partially dependent on Pak2-mediated phosphorylation of Myc. Genome-wide analysis of NB4 cells treated with RA, AraC with RA, or MycD with RA revealed a significant 60% overlap between RA-target genes superactivated by AraC with RA, or MycD with RA, with respect to RA alone.

2012-01-05 | GSE29213 | GEO

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