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Agaricus blazei

ABSTRACT: Agaricus blazei overview

PROVIDER: PRJNA605060 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
		Other
	SSNC01.dat.gz	Other
	SSNC01.fasta.gz	Fasta.gz
	SSNC01.master.dat	Other

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1 - 4 of 4

Similar Datasets

Agaricus blazei

Project description:Agaricus blazei Assembly

| PRJNA531725 | ENA

Agaricus blazei

Project description:Agaricus blazei Genome sequencing

| PRJNA400535 | ENA

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE)

2014-01-01 | GSE30193 | GEO

Gene expression profiles in patients with multiple myeloma receiving adjuvant treatment with an extract from the mushroom agaricus blazei Murill in addition to chemotherapy

2014-08-28 | GSE60869 | GEO

Transcription profiling of human monocyte cell line treated with medicinal extract from Agaricus blazei Murill

Project description:The effect on gene expression of an extract from a medicinal mushroom (Agaricus blazei Murill)were compared with the effect of lipopolysaccharides (LPS). Both are potent immunomodulators. The study used a monocyte cell line.

2013-01-29 | E-BASE-1 | biostudies-arrayexpress

Agaricus blazei strain:JA

Project description:Agaricus blazei strain:JA Transcriptome or Gene expression

| PRJNA541375 | ENA

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

2014-01-01 | E-GEOD-30193 | biostudies-arrayexpress

Gene expression profiles in patients with multiple myeloma receiving adjuvant treatment with an extract from the mushroom agaricus blazei Murill in addition to chemotherapy

Project description:The edible mushroom Agaricus blazei Murill has immunomodulating and antiproliferative effects. In a clinical study 33 patients with multiple myeloma were randomized to receive treatment with Agaricus (16 patients) or placebo (17 patients) in addition to chemotherapy. Gene expression profiles were analyzed before and after treatment in 8 patients in the agaricus group and in 6 patients in the control group and the differences were calculated

2014-08-28 | E-GEOD-60869 | biostudies-arrayexpress

Agaricus blazei strain:JA-15036

Project description:Agaricus blazei strain:JA-15036 Genome sequencing and assembly

| PRJNA532471 | ENA

Pancreatic adenocarcinoma cell lines were treated with Agaricus blazei Murrill hot water extract (AbE).

Project description:Pancreatic cancer is one of the most aggressive human malignancies with 7.1% five-year survival rate due to late-stage diagnosis and lack of effective treatment. A novel active compound to be useful for treating pancreatic cancer is absolutely demanded. Agaricus blazei (A. blazei) Murrill has been shown to have an anti-cancer activity, however, its specific efficacy and underlying mechanism is poorly understood. Here, we demonstrated that A. blazei hot water extract (AbE) showed significant growth inhibition of cultured pancreatic cancer cells with less suppressive effect on the normal human pancreatic duct epithelial cells. The pancreatic cancer cells committed G0/G1 cell cycle arrest and caspase-dependent apoptosis. Moreover, we uncovered significant alterations of global gene expression in the pancreatic cancer cells by AbE treatment. Signature of alteration of gene expression indicated that AbE induced repression of genes associated with kinetochore function, spindle formation, centromere maintenance, and cyclins and cyclin dependent kinases, which were essential for cell cycle progression. The gene expression analysis also showed upregulation of proapoptotic genes. These results indicate that AbE could be useful for treatment of pancreatic cancer and a good candidate to isolate potent active compound for development of novel drug for pancreatic cancer.

2018-10-31 | GSE89396 | GEO

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