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IER5 is a novel Notch target gene that contributes to the effects of Notch on breast cancer stem / progenitor cells

ABSTRACT: The Notch signalling pathway has been implicated in the development and progression of numerous malignancies, including breast cancer. In breast cancer, the transcriptional programs elicited by Notch activation and the target genes responsible for mediating the downstream effects of the pathway remain poorly understood. Here, we characterise the immediate cellular consequences of Notch activation in breast cancer cells and identify a panel of direct Notch targets with potential relevance in the disease. One key direct transcriptional target of Notch in this context is IER5. Functionally, IER5 activation in breast cancer contributes to the effects of Notch signalling on the self-renewal and proliferative potential of breast cancer stem and progenitor cells. High levels of IER5 mRNA may be an important biomarker indicative of Notch activation in the disease.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30288 | GEO | 2018/01/08

SECONDARY ACCESSION(S): PRJNA143591

REPOSITORIES: GEO

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