Methylation profiling

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Methylation analysis of 81 glioma clinical samples (49 CIMP+ and 32 CIMP-) and 53 cell line samples


ABSTRACT: Glioma CIMP (G-CIMP) is a powerful determinant of tumor pathogenicity but the molecular cause of G-CIMP is a fundamental question that is unresolved. Here, we show that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), directly causes the G-CIMP in gliomas by remodeling the methylome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE30338 | GEO | 2012/02/16

SECONDARY ACCESSION(S): PRJNA154817

REPOSITORIES: GEO

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