Dataset Information

CImP: Cellular Imprinting Proteomics applied to ocular disorders

ABSTRACT: A method (termed Cellular Imprinting Proteomics, CImP) for the identification and quantification of the ocular surface proteome using a minimally invasive membrane filter device is described. Moreover, The CImP method was applied to profile the molecular alterations in the eyes of infants exposed to Zika virus (ZIKV) infection during gestation.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Eye Epithelium

DISEASE(S): Viral Infectious Disease

SUBMITTER: Livia Rosa-Fernandes

LAB HEAD: Giuseppe Palmisano

PROVIDER: PXD014038 | Pride | 2020-07-23

REPOSITORIES: Pride

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Publications

Cellular Imprinting Proteomics Assay: A Novel Method for Detection of Neural and Ocular Disorders Applied to Congenital Zika Virus Syndrome.

Rosa-Fernandes Livia L Barbosa Raquel Hora RH Dos Santos Maria Luiza B MLB Angeli Claudia B CB Silva Thiago P TP Melo Rossana C N RCN de Oliveira Gilberto Santos GS Lemos Bernardo B Van Eyk Jennifer E JE Larsen Martin R MR Cardoso Claudete Araújo CA Palmisano Giuseppe G

Journal of proteome research 20200804 11

Congenital Zika syndrome was first described due to increased incidence of congenital abnormalities associated with Zika virus (ZIKV) infection. Since the eye develops as part of the embryo central nervous system (CNS) structure, it becomes a specialized compartment able to display symptoms of neurodegenerative diseases and has been proposed as a noninvasive approach to the early diagnosis of neurological diseases. Ocular lesions result from defects that occurred during embryogenesis and can bec ...[more]

PMID: 32686424

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	LUM2_03284_LR_AP-D1.raw	Raw