Gene Expression Patterns of Endothelial Cell Network Formation
Ontology highlight
ABSTRACT: Lamellar co-cultures of human aorta-derived smooth muscle cells (SMCs) cultured with cord-blood derived endothelial cells (ECs) are an in vitro model for tissue engineered blood vessels and in-growth of endothelial cells into cardiovascular repair devices. The ratio of endothelial cells to smooth muscle cells can control the EC pattern of growth and differentiation. Low density ECs form capillary-like networks in co-culture with SMCs whereas high density ECs become confluent across the top surface of the SMCs. To understand the molecular mechanisms that govern network formation, used microarray analysis of ECs purified from 1) networks, 2) confluent layers compared to 3) ECs in monoculture.
ORGANISM(S): Homo sapiens
PROVIDER: GSE30527 | GEO | 2017/03/01
SECONDARY ACCESSION(S): PRJNA143307
REPOSITORIES: GEO
ACCESS DATA