Iron excess limits HHIPL2 gene expression and decreases osteoblastic activity in human MG-63 cells
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ABSTRACT: Our transcriptomic data shows that iron impact on human osteoblastic MG-63 cells by decreasing HHIPL-2 gene expression (2 fold ratio). This impact is corrected in presence of deferoxamine. Additional biological experiments in the manuscript suggest that the iron related modulation of HHIPL-2 gene expression could take place in the decrease of osteoblastic markers in the MG-63 cell line. Such mechanisms could participate to the development of osteoporosis in iron overloaded patients.
ORGANISM(S): Homo sapiens
PROVIDER: GSE30774 | GEO | 2012/09/01
SECONDARY ACCESSION(S): PRJNA144325
REPOSITORIES: GEO
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