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Detection of oncoantigens suitable for lung cancer vaccination

ABSTRACT: The lung cancer tumor K-rasLA1/ p53 R172HDeltag mouse model was used to identify genes associated to the tumor mass increase in lungs. Those genes were then ranked on the basis of their oncogenic potential using a metadataset encompassing 695 human lung adenocarcinomas and ranking them on the basis of their expression in normal tissues. The genes characterized by the higher oncogenic potential combined to a low expression in normal tissues were selected as putative targets for preclinical studies on lung cancer vaccination.

ORGANISM(S): Mus musculus

PROVIDER: GSE30878 | GEO | 2013/12/30

SECONDARY ACCESSION(S): PRJNA144265

REPOSITORIES: GEO

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