Endogenous CD4+ T Cells Recognize Neoantigens in Lung Cancer, including KRAS and Her2
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ABSTRACT: Neoantigen-specific T cell responses were characterized in 4 patients with non-small cell lung cancer. Candidate neoantigens were identified by sequencing tumor and normal DNA from each patient, and ranking single nucleotide variants by expression. Multiple T cell responses were isolated, and in two patients with lung adenocarcinoma, CD4+ T cell responses to recurrent oncogenic mutations in KRAS and Her2 were identified.
REPOSITORIES: dbGaP
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