Transcriptomics

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Cdc14 as transcription regulator of RNA pol-II


ABSTRACT: In yeast, the phosphatase Cdc14 is required for mitotic exit and for segregation of repetitive regions. Cdc14 is also a subunit of the silencing complex RENT, but no roles in transcription repression have been described. Here we report that Cdc14 promotes silencing at the integenic spacer sequences (IGS) of ribosomal genes during interphase and at Y' repeats in sub-telomeric regions during mitosis, through its ability to dephosphotylate the CDT domain of the RNA polymerase II.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE31020 | GEO | 2011/07/29

SECONDARY ACCESSION(S): PRJNA144921

REPOSITORIES: GEO

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