Expression data from treatment-induced senescence in mouse Emu-myc B-cell lymphoma model
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ABSTRACT: Treatment induced senescence (TIS) is a terminal cell cycle arrest program, increasingly recognized as a tumor suppressor mechanism complementing apoptosis in response to standard chemotherapy regimens. In particular cells with blocked apoptotic pathways rely on senescence as the only remaining failsafe mechanism to keep the neoplastic growth in check. However, little is known about biological properties, long-term fate of senescent tumor cells and their impact on the microenvironment. We used global gene expression profiling by microarrays to gain insight in the molecular programme underlying the treatment-induced senescence in Emu-myc transgenic B-cell lymphomas (apoptosis protected by Bcl2 overexpression), which robustly enter senescence in response to DNA-damaging anticancer agents such as Adriamycin (ADR).
ORGANISM(S): Mus musculus
PROVIDER: GSE31099 | GEO | 2011/11/21
SECONDARY ACCESSION(S): PRJNA144689
REPOSITORIES: GEO
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