Dataset Information
Senescence 3 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Breast Cancer
SUBMITTER: 
judith coppinger
LAB HEAD: Judith Coppinger
PROVIDER: PXD001014 | Pride | 2015-08-21
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| peptides.pep.xml | Pepxml | |||
| peptides_1_1_0.mzid.gz | Mzid | |||
| peptides_1_1_0.pride.mztab.gz | Mztab | |||
| s14sen1prol-01.RAW | Raw | |||
| s14sen1prol-01.mgf | Mgf |
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Publications
Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
Molecular & cellular proteomics : MCP 20140705 1
Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectr ...[more]