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Gene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance

ABSTRACT: During the course of adjuvant arthritis, maximal changes in gene expression were observed at the incubation phase. A major group of genes affected was related to immune activity. Tolerance induction by mycobacterial heat-shock protein 65 (Bhsp65), the disease-related antigen, caused upregulation of a large number of genes. These included immune activity genes as well as cell proliferation-related genes. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE31314 | GEO | 2011/11/16

SECONDARY ACCESSION(S): PRJNA146083

REPOSITORIES: GEO

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Gene expression profile of preclinical arthritis and its modulation by antigen-induced tolerance

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