Cis-Expression QTL Analysis of Established Risk Variants for Colorectal Cancer
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ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE31737 | GEO | 2012/01/31
SECONDARY ACCESSION(S): PRJNA145435
REPOSITORIES: GEO
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Project description:Genome-wide association studies (GWAS) have identified 19 risk variants associated with colorectal cancer. As most of these risk variants reside outside the coding regions of genes, we conducted cis-expression quantitative trait loci (cis-eQTL) analyses to investigate possible regulatory functions on the expression of neighboring genes. Forty microsatellite stable and CpG island methylator phenotype-negative colorectal tumors and paired adjacent-normal colon tissues were used for genome-wide SNP and gene expression profiling in our cis-eQTL analyses. This submission represents transcriptome component of study.
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