Genomics

Dataset Information

0

RNA-sequencing of left and right atrial


ABSTRACT: The right and left atria have different susceptibilities towards developing arrhythmias, with left atrial arrhythmias more commonly observed. To study potential underlying causes of this difference between the two upper chambers of the heart, four human left-right atrial pairs were subjected to whole-genome expression analyses via next generation sequencing of small RNAs, including microRNAs (miRNAs), and polyA enriched mRNAs. Using a paired sample design, significant differences in gene expression were found between the left and right atria in both the poly-A and small RNA fractions. Hsa-miR-143 was the most highly expressed miRNA in the atria as quantified by RNA-seq. Gene expression differences established during development are retained into adulthood including that of PITX2 and BMP10. In addition ten novel non-coding RNAs were found to be differentially expressed between the left and right atrias .

ORGANISM(S): Homo sapiens

PROVIDER: GSE31999 | GEO | 2011/09/10

SECONDARY ACCESSION(S): PRJNA145151

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-06-19 | GSE152181 | GEO
2019-03-13 | GSE128188 | GEO
2020-07-01 | GSE138253 | GEO
2022-09-18 | GSE213514 | GEO
2010-06-16 | E-GEOD-22170 | biostudies-arrayexpress
2020-09-11 | GSE138252 | GEO
| PRJNA638591 | ENA
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
2016-08-09 | E-GEOD-79768 | biostudies-arrayexpress
2010-07-31 | E-GEOD-12755 | biostudies-arrayexpress