Transcriptomics

Dataset Information

0

Immune related gene expression comparison between human CD14+ HLA-DR-neg/low MDSC vs CD14+ HLA-DR-high control monocytes


ABSTRACT: Myeloid-derived suppressor cells (MDSC) is a heterogeneous population of cells that can negatively regulate T-cell function. As opposed to murine MDSC, which are characterized as Gr-1+CD11b+ cells, human MDSC are not so clearly defined due to lack of specific markers. Our lab has previously identified a new subset of MDSC as CD14+HLA-DR-neg/low cells from PBMC. CD14+HLA-DR-neg/low MDSC not only suppress proliferation and IFN-gamma secretion of autologous T cells, but also induce CD25+Foxp3+ regulatory T cells that are suppressive in vitro, whereas the counterpart CD14+HLA-DR-high monocytes don’t have the effect. In this study, we compare the immune-related gene expression between CD14+HLA-DR-neg/low MDSC and CD14+HLA-DR-high monocytes to better characterize the difference between these two populations and to find new potential specific marker for human MDSC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE32001 | GEO | 2011/09/09

SECONDARY ACCESSION(S): PRJNA145155

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-09-08 | E-GEOD-32001 | biostudies-arrayexpress
2022-05-31 | GSE183768 | GEO
| PRJNA145155 | ENA
2021-12-22 | GSE192350 | GEO
| PRJNA761999 | ENA
2022-06-02 | GSE205122 | GEO
2016-01-25 | PXD002951 | Pride
2016-04-13 | MSV000079647 | MassIVE
2015-09-01 | E-GEOD-49782 | biostudies-arrayexpress
2019-05-30 | GSE131552 | GEO