Transcriptomics

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Four subgroups by gene expression profile correlate with biological and clinical features in colorectal cancer.


ABSTRACT: (Purpose) Biological classification of colorectal cancer (CRC) can help to understand its heterogeneous background. The purpose of this study is to classify CRC based on gene expression profiles using formalin-fixed paraffin-embedded (FFPE) samples and to correlate subgroups of CRC with biological features and clinical outcomes. (Results) CRC was clustered into four subgroups by unsupervised hierarchical clustering method. These subgroups show different biological and clinical features. (Conclusion) Gene expression profiles of CRC using FFPE samples distinguish four subgroups that had different biological features and clinical outcomes. These subgroups may explain heterogeneity of CRC and be useful biomarker for clinical.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33193 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA149243

REPOSITORIES: GEO

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