Transcriptomics

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A 5-gene signature predicts outcome in women with hormone receptor-negative early breast cancer treated with chemoterapy.


ABSTRACT: Hormone-receptor negative (HR-) breast cancer accounts for approximately one third of all breast tumors and has a worse prognosis compared with hormone receptor-positive disease. Their unfavorable outcome and the lack of hormonal receptors determine the use of adjuvant chemotherapy as part of the standard treatment for these tumors. However, a significant proportion of patients relapse after receiving adjuvant chemotherapy. Classical prognostic factors such as tumor size, lymph node status and grade of differentiation do not suffice to identify patients with a higher risk of relapse. In the last decade, gene profiling has allowed the description of signatures with prognostic value in hormone receptor-positive tumors, but similar information is scarce in HR- disease. Reliable identification of poor-prognosis patients would be important to offer participation in clinical trials with new drugs and to modify follow-up schedules. In this study, we assessed gene expression with quantitative polymerase-chain reaction (RT-qPCR) in HR- early stage breast cancer. RNA was isolated from formalin-fixed paraffin-embedded (FFPE) tissue. Our purpose was to identify a gene signature related to outcome.

ORGANISM(S): Homo sapiens

PROVIDER: GSE33669 | GEO | 2016/02/01

SECONDARY ACCESSION(S): PRJNA148729

REPOSITORIES: GEO

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