A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
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ABSTRACT: Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzymatic activity drives synthetic lethality with Myc. Mechanistically, SAE2 inhibition switches a transcriptional subprogram of Myc from activated to repressed. A subset of these SUMOylation-dependent Myc-switchers (SMS genes) governs mitotic spindle function and is required to support the Myc oncogenic program.
ORGANISM(S): Homo sapiens
PROVIDER: GSE34055 | GEO | 2011/12/08
SECONDARY ACCESSION(S): PRJNA150021
REPOSITORIES: GEO
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