Transcriptomics

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Gene expression profiling of two diffuse large B-cell lymphoma (DLBCL) cell lines, DHL4 and DHL6, treated with the SYK inhibitor, R406


ABSTRACT: The two DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent phosphorylation of BCR signaling components such as BLNK.

ORGANISM(S): Homo sapiens

PROVIDER: GSE34176 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA149685

REPOSITORIES: GEO

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