Transcriptomics

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Differential regulation of intestinal lipid metabolism in A/J versus C57BL/6J mice during diet-induced obesity


ABSTRACT: The effects of high-fat (HF) feeding on the gene expression in the small intestine were examined using obesity-resistant A/J mice and obesity-sensitive C57BL/6J (B6) mice. Both strains of mice were maintained on low-fat (LF, 5% fat) or HF (30% fat) diets for two weeks. Oligonucleotide microarray and semi-quantitative RT-PCR analysis revealed that lipid metabolism-related genes including mitochondrial acyl-CoA thioesterase 1, pyruvate dehydrogenase kinase 4, and NADP+-dependent cytosolic malic enzyme were up-regulated by more than 2-fold in both strains of mice. The up-regulated gene expression levels were significantly higher in A/J mice than in B6 mice, suggesting the active lipid metabolism in the small intestine of A/J mice. Keywords: diet response, strain difference

ORGANISM(S): Mus musculus

PROVIDER: GSE3433 | GEO | 2007/08/27

SECONDARY ACCESSION(S): PRJNA93467

REPOSITORIES: GEO

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