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MiRNA expression profile in murine advanced atherosclerotic plaque compared with early atherosclerotic plaque

ABSTRACT: Aberrantly expressed miRNAs contribute to developmental abnormalities and diseases such as cancer, diabetes, and cardiovascular disorders, by hybridizing to specific mRNA targets and repressing their translation into proteins. Although miRNA expression signature is characterized in the process of neointimal thickening during proliferative vascular diseases such as atherosclerosis, so far global miRNA expression profiling in the different stages of atherosclerosis is completely unknown. We explored stage-specific microRNA signatures in the progress of atherosclerosis in hyperlipidemia mouse model, which may help to identify the critical miRNAs contributing atherosclerotic development and stabilization.

ORGANISM(S): Mus musculus

PROVIDER: GSE34647 | GEO | 2013/03/27

SECONDARY ACCESSION(S): PRJNA156365

REPOSITORIES: GEO

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