Genomics

Dataset Information

0

The Kdm5c histone demethylase controls enhancer and promoter function.


ABSTRACT: Here, we show that the Kdm5c/Smcx member of the Jarid1 family of H3K4 demethylases is recruited to both enhancer and core promoter elements in ES and neuronal progenitor cells (NPC). Knockdown of Kdm5c deregulates transcription via a local increase in H3K4me3. While at core promoters the function of Kdm5c is to restrict transcription, loss of Kdm5c impairs enhancer function. Remarkably, an impaired enhancer function activates promoter activity from Kdm5c-bound intergenic regions. Our results demonstrate that the Kdm5c demethylase plays a crucial role in the functional identity and discrimination of enhancers and core promoters. We speculate that this is related to recruitment of H3K4me3 binders like the TFIID and NURF complexes6-8. Providing functional identity to genomic regions through balancing enzymes that deposit and remove histone modifications may prove to be a general epigenetic mechanism for the functional indexing of eukaryotic genomes.

ORGANISM(S): Mus musculus

PROVIDER: GSE34975 | GEO | 2013/04/01

SECONDARY ACCESSION(S): PRJNA151105

REPOSITORIES: GEO

Shared Molecules

Only show the datasets with similarity scores above: 0.5
     

Similar Datasets

2013-04-01 | E-GEOD-34975 | biostudies-arrayexpress
2013-04-05 | E-GEOD-38862 | biostudies-arrayexpress
2013-04-05 | GSE38862 | GEO
2013-07-18 | E-GEOD-48960 | biostudies-arrayexpress
2013-07-18 | GSE48962 | GEO
2013-07-18 | GSE48960 | GEO
2013-07-18 | E-GEOD-48962 | biostudies-arrayexpress
2022-04-14 | GSE96740 | GEO
2023-03-10 | PXD016568 | Pride
2016-01-27 | GSE75866 | GEO