Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard van Schaik
PROVIDER: E-GEOD-34975 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell reports 20130328 4
The functional organization of eukaryotic genomes correlates with specific patterns of histone methylations. Regulatory regions in genomes such as enhancers and promoters differ in their extent of methylation of histone H3 at lysine-4 (H3K4), but it is largely unknown how the different methylation states are specified and controlled. Here, we show that the Kdm5c/Jarid1c/SMCX member of the Kdm5 family of H3K4 demethylases can be recruited to both enhancer and promoter elements in mouse embryonic ...[more]