Transcriptomics

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Effects of Cardiac Glycosides on RNA Expression in Prostate Cancer LNCaP-abl Cells


ABSTRACT: Prostate cancer is the most common cancer in men and cardiac glycosides inhibit prostate cancer cell proliferation. In order to investigate the mechanism by which cardiac glycosides inhibit prostate cancer cells, we observed genome-wide RNA expression in prostate cancer LNCaP-abl cells, hormone resistant cells, after the cardiac glycoside treatment using RNA-Seq. In addition, we profiled LNCaP-abl cells after androgen receptor (AR) knockdown to observe whether cardiac glycoside effect on RNA expression is similar to that of AR knockdown.

ORGANISM(S): Homo sapiens

PROVIDER: GSE35126 | GEO | 2012/04/04

SECONDARY ACCESSION(S): PRJNA150723

REPOSITORIES: GEO

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