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Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development

ABSTRACT: We investigated Smad4-mediated TGF-beta signaling in the development of occipital somite-derived myogenic progenitors during tongue morphogenesis by comparing the transcriptomes of tongue derived from Myf5-Cre;Smad4flox/flox mutant and Myf5-Cre;Smad4flox/+ control mice at day E13.5. Based on gene expression profiles and functional studies, we elucidated the influences Smad4 activity and TGF-beta signaling have on the gene expression profiles underlying tongue development. The data are consistent with the hypothesis that TGF-beta-Smad4-FGF6 signaling cascade plays a crucial role in myogenic cell fate determination and lineage progression during tongue myogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE35357 | GEO | 2012/02/03

SECONDARY ACCESSION(S): PRJNA152741

REPOSITORIES: GEO

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Gene expression profiling of Myf5-Cre;Smad4flox/flox mouse models of tongue development

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