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Global transcriptional profile at a higher fermentation temperature in S.avermitilis NRRL8165

ABSTRACT: To explore the molecular mechanism of the positive thermoregulation on Jinggangmycin A biosynthesis, the transcriptomes of S. hygroscopicus 5008 cultivated at 30℃ or 37℃ in liquid medium were compared by microarray analysis. Additionally, the transcriptomes of S. avermitilis NRRL8165 cultivated at the same conditions were analyzed in parallel to filter transcriptional changes common to Streptomyces genus.

ORGANISM(S): Streptomyces avermitilis

PROVIDER: GSE35611 | GEO | 2012/02/09

SECONDARY ACCESSION(S): PRJNA152541

REPOSITORIES: GEO

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Global transcriptional profile at a higher fermentation temperature in S.avermitilis NRRL8165

Project description:To explore the molecular mechanism of the positive thermoregulation on Jinggangmycin A biosynthesis, the transcriptomes of S. hygroscopicus 5008 cultivated at 30℃ or 37℃ in liquid medium were compared by microarray analysis. Additionally, the transcriptomes of S. avermitilis NRRL8165 cultivated at the same conditions were analyzed in parallel to filter transcriptional changes common to Streptomyces genus. Global gene expression in NRRL8165 was measured at 30℃ or 37℃, respectively. Three independent experiments were performed at each condition.

2012-02-09 | E-GEOD-35611 | biostudies-arrayexpress

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Global transcriptional profiles response to strain variation and medium change for validamycin overproduction

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