Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cardiac over-expression of Med13

ABSTRACT: Med13 cardiac over-expression regulates cardiac gene expression and metabolism

ORGANISM(S): Mus musculus

PROVIDER: GSE35902 | GEO | 2012/02/18

SECONDARY ACCESSION(S): PRJNA155687

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cardiac over-expression of Med13

Project description:Med13 cardiac over-expression regulates cardiac gene expression and metabolism Hearts from Med13 alphaMHC transgenic mice and wild type littermates

2012-02-18 | E-GEOD-35902 | biostudies-arrayexpress

Cardiac over-expression of Med13, non-cardiac tissue analysis

Project description:Med13 cardiac over-expression regulates obesity. Liver, WAT and BAT from alphaMHC-Med13 TG mice was analyzed

2012-02-18 | GSE35903 | GEO

Cardiac over-expression of Med13, non-cardiac tissue analysis

Project description:Med13 cardiac over-expression regulates obesity. Liver, WAT and BAT from alphaMHC-Med13 TG mice was analyzed Liver, WAT and BAT from Med13 alphaMHC transgenic mice and wild type littermates

2012-02-18 | E-GEOD-35903 | biostudies-arrayexpress

Med13 overexpression

Project description:This SuperSeries is composed of the following subset Series: GSE35902: Cardiac over-expression of Med13 GSE35903: Cardiac over-expression of Med13, non-cardiac tissue analysis Med13 cardiac transgenic mice were back-crossed 4 or more generations to C57Bl6 mice. Refer to individual Series

2012-02-18 | E-GEOD-35904 | biostudies-arrayexpress

Regulation of cardiac transcription by thyroid hormone and Med13

Project description:Purpose: The objective of this study was to determine cardiac transcriptional pathways regulated in response to 1.) hypothyroidism and re-establishment of a euthyroid state and 2.) Med13-dependent cardiac transcriptional pathways regulated in response to hypothyroidism and re-establishment of a euthyroid state

2019-05-15 | GSE124117 | GEO

Regulation of cardiac transcription by thyroid hormone and Med13

Project description:Regulation of cardiac transcription by thyroid hormone and Med13

| PRJNA510801 | ENA

Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line

Project description:Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line

| PRJNA1054158 | ENA

Mus musculus

Project description:Cardiac over-expression of Med13

| PRJNA155687 | ENA

Mus musculus

Project description:Cardiac over-expression of Med13, non-cardiac tissue analysis

| PRJNA155689 | ENA

Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line

Project description:The eukaryotic transcriptional Mediator comprises a large Core (cMED) and a dissociable CDK8 kinase module (CKM). cMED recruits RNA polymerase II (Pol II) and promotes pre-initiation complex formation in a manner repressed by the CKM through mechanisms presently unknown. Herein we report cryo-electron microscopy structures of the complete human Mediator and its CKM. Combined with biochemical and functional analyses, these structures provide a mechanistic framework to explain the basis for CKM-mediated repression of cMED function. The CKM binds to cMED at multiple sites through both MED12 and a large intrinsically disordered region (IDR) in MED13. The MED13 IDR blocks Pol II/MED26 recruitment onto cMED by direct occlusion of their corresponding binding sites, leading to functional repression of cMED-dependent transcription. Notably, the CKM is anchored to the cMED Hook, positioning CDK8 downstream and proximal to the transcription start site, which sheds new light on its stimulatory function in post-initiation events.

2024-12-01 | GSE250492 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data